PAT SENSOR CASE STUDY
Innopharma Technology’s Multieye2 is a multipoint near-infrared (NIR) spectrometer designed for real-time in-line process monitoring. It has a single sensor with up to four discrete channels that allows measurements from four probes within a process, removing the need for time-consuming alignment processes and channel-to-channel variance that numerous single point systems often have.
This multipoint near-infrared (NIR) spectrometer is ideal for use in;
- advanced development and manufacturing to aid rapid identification
- monitoring and control of critical quality attributes and critical process parameters as part of a process control strategy
Multieye2 can be used to monitor API/component concentration and can also be implemented in applications where blend uniformity, moisture content and ribbon density are of interest.
In a study carried out by the University of Eastern Finland in their continuous processing lab in the School of Pharmacy, Kuopio, Innopharma Technology’s NIR spectroscopy PAT sensor, Multieye2, was used to track the API concentration of the powder being outputted by a continuous blender.
The objective of this study was to examine the ability of the NIR spectroscopy PAT sensor to accurately monitor the concentration of API being added to the product by the continuous blending system.
The powder blend contained two ingredients: the excipient, Prosolv EasyTab SP, and the API, paracetamol, which was being monitored. The powders were fed into the blender through separate feeders, and the paracetamol concentration was changed throughout the experiment.
The experiment found that the NIR Spectrometer can be used successfully for monitoring of continuous blending operations by doing the following;
- Measuring different levels (5%, 10%, 15% and 20%) of paracetamol concentration, as may be required for varying product SKUs
- Detecting spikes of varying magnitude (2.5 g, 5 g, 10 g and 15 g) of paracetamol coming from the blender, allowing for real-time detection of changes in the process
So if you are looking to:
- Capture the impact of your critical process parameters with real-time data analysis
- Reduce testing time and increase the quality
- Enable quick decision-making during product development and manufacturing
Then the Multieye2 NIR spectroscopy PAT sensor might just be what you’re looking for
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